Clinical use of H1-antihistamines

H1 antihistamines and driving

Driving performances depend on cognitive, psychomotor and perception functions. The CNS adverse effects of some H1 antihistamines can alter the patient ability to drive. Data from studies using standardized objective cognitive and psychomotor tests (Choice Reaction Time, Critical Flicker Fusion. Digital Symbol Substitution Test), functional brain imaging (Positron Emission Tomography, functiona...

Use of second generation H1 antihistamines in special situations.

Antihistamine drugs are one of the therapeutic classes most used at world level, at all ages and in multiple situations. Although in general they have a good safety profile, only the more recent drugs (second generation antihistamines) have been studied specifically with regard to the more important safety aspects. Given the variety of antihistamine drugs, they cannot all be considered equivale...

Interactions of the H1 antihistamines.

An interaction is taken to be the situation in which the administration of a drug or substance induces changes in the pharmacokinetics of another simultaneously administered drug – either increasing or decreasing the plasma concentration of the latter, and thus giving rise to the possibility of adverse reactions [1]. According to the primarily responsible pharmacological mechanism, H 1 antihist...

Clinical pharmacokinetics of H1-receptor antagonists (the antihistamines).

This article reviews clinical pharmacokinetic data on the H1-receptor antagonists, commonly referred to as the antihistamines. Despite their widespread use over an extended period, relatively little pharmacokinetic data are available for many of these drugs. A number of H1-receptor antagonists have been assayed mainly using radioimmunoassay methods. These have also generally measured metabolite...

Comparative pharmacology of the H1 antihistamines.