Clinical Significance of Statin Pleiotropic Effects
نویسندگان
چکیده
منابع مشابه
Clinical significance of statin pleiotropic effects: hypotheses versus evidence.
The word “pleiotropic” usually is applied to genetics, referring to the multiple actions of a single gene. Regarding drug therapy for dyslipidemia, however, the term has become synonymous with clinical benefits beyond the effects of the drug on lipoproteins. HMG-CoA reductase inhibitors (statins), as the most widely prescribed drugs in the world, have been extensively evaluated for effects inde...
متن کاملPotential statin-drug interactions: prevalence and clinical significance
BACKGROUND Statins are cholesterol-lowering drugs widely used for cardiovascular prevention. Although safe when used alone, in combination with other drugs the likelihood of adverse drug reactions increases significantly. The exposure of the Bulgarian population to coprescriptions leading to potential statin-drug interactions is currently unknown. OBJECTIVE The aim of this study was to invest...
متن کاملOngoing Clinical Trials of the Pleiotropic Effects of Statins
BACKGROUND The multiple effects (ie, pleiotropic effects of statins) have received increasing recognition and may have clinical applicability across a broad range of cardiovascular and noncardiovascular conditions. OBJECTIVE To determine the relevance and significance of ongoing clinical trials of the pleiotropic effects of statins, focusing on nonlipid effects. METHOD Ongoing trials were i...
متن کاملPleiotropic effects of niacin: Current possibilities for its clinical use.
Niacin was the first hypolipidemic drug to significantly reduce both major cardiovascular events and mortality in patients with cardiovascular disease. Niacin favorably influences all lipoprotein classes, including lipoprotein[a],and belongs to the most potent hypolipidemic drugs for increasing HDL-C. Moreover, niacin causes favorable changes to the qualitative composition of lipoprotein HDL. I...
متن کامل[Pleiotropic effects of statins].
Results of numerous epidemiologic studies indicate that elevated serum cholesterol, especially the LDL fraction, is a major cause of coronary heart disease (CHD). Epidemiologic and angiographic evidence from primary and secondary prevention studies involving several HMG-CoA reductase inhibitors (statins) indicate that decreasing elevated serum cholesterol concentration (specifically LDL-cholest...
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ژورنال
عنوان ژورنال: Circulation
سال: 2005
ISSN: 0009-7322,1524-4539
DOI: 10.1161/01.cir.0000167560.93138.e7