Clinical significance of microRNA-625 expression in colorectal cancer

MicroRNA expression in colorectal cancer.

Clinical significance of the expression of connexin26 in colorectal cancer

BACKGROUND Connexin26 (Cx26) is one of the connexins (Cxs) family members which form gap junction channels. Cx26 is considered to be a tumor suppressor gene. However, recent studies revealed that over expression of Cx26 is associated with a poor prognosis in several human cancers. This study investigated the correlation between Cx26 expression and the clinicopathological features and P53 expres...

Clinical significance of HSP27 expression in colorectal cancer.

The heat shock protein 27-kDa (HSP27) has been found overexpressed in several types of human cancer and is associated with treatment resistance and poor prognosis. Recent proteomic studies demonstrate that HSP27 is significantly overexpressed in colorectal cancer (CRC). However, the relationship between HSP27 expression and patient prognosis remains nascent. In the present study, we aimed to in...

Clinical significance of TROP2 expression in colorectal cancer.

PURPOSE AND EXPERIMENTAL DESIGN To identify cancer-related genes, the expression profiles of colorectal cancer cells and normal epithelial cells were examined and compared using laser microdissection and cDNA microarray analysis. From these combined techniques, several cancer-related genes, including TROP2, were identified. TROP2 is known as a calcium signal transducer and is highly expressed i...

Clinical significance of fibronectin expression in colorectal cancer.

We measured the serum and urinary levels of fibronectin (FN) in 113 patients with colorectal cancer (CRC) - 15 with synchronous hepatic metastases, 21 with metachronous hepatic metastases and 77 with no hepatic metastases - as well as in 40 controls, with the aim of determining if FN can be used as a marker of CRC invasion or metastasis and its clinical significance. Urinary FN levels were sign...