Clinical research: Efficacy studies v basic research

Clinical Implications of Basic Research

ETASTASIS is the chief cause of morbidity and mortality in most cancers. Appropriately, the words " cancer " (from the Latin for " crab ") and " me-tastasis " (from the Greek for " change in position ") both refer to cell movement: the crab-like invasion of cancer into healthy tissue and the migration of cancer cells to sites distant from the primary tumor. Since the work of Paget more than 100...

Clinical Implications of Basic Research

YTOTOXIC T lymphocytes control viral infections by lysing infected cells and secreting soluble factors (cytokines) that enhance antiviral immunity and suppress infection. The importance of antiviral killer cells in controlling acute infection with human immunodeficiency virus (HIV) and the related simian immunodeficiency virus (SIV) in macaque monkeys has clearly been demonstrated: resolution o...

Clinical Implications of Basic Research

ULTIPLE sclerosis is the most common nontraumatic disorder of the central nervous system in young adults. Twenty years after the onset of disease, 90 percent of cases will have entered a progressive phase. Strong circumstantial evidence implicates an autoimmune mechanism in multiple sclerosis. The results of family studies illustrate the importance of genes in the familial aggregation of the di...

Contributions of basic research to clinical medicine.

Breast Cancer: Basic and Clinical Research

Background: Chemotherapy for breast cancer often deteriorates quality of life, augments fatigue, and induces neutropenia. Mistletoe preparations are frequently used by cancer patients in Central Europe. Physicians have reported better quality of life in breast cancer patients additionally treated with mistletoe preparations during chemotherapy. Mistletoe preparations also have immunostimulant p...