Clinical relevance of Wilms tumor 1 gene mutations in childhood acute myeloid leukemia
نویسندگان
چکیده
منابع مشابه
MYELOID NEOPLASIA Clinical relevance of Wilms tumor 1 gene mutations in childhood acute myeloid leukemia
1Department of Pediatric Oncology/Hematology, Erasmus MC–Sophia Children’s Hospital, Rotterdam, The Netherlands; 2AML-BFM Study Group, Department of Pediatric Oncology/Hematology, Medical High School, Hannover, Germany; 3Clincial Genetics, Academic Medical Center, Amsterdam, The Netherlands; 4Department of Hematology and Oncology, University Children’s Hospital of Frankfurt, Frankfurt, Germany;...
متن کاملClinical relevance of Wilms tumor 1 gene mutations in childhood acute myeloid leukemia.
Wilms tumor 1 (WT1) mutations have recently been identified in approximately 10% of adult acute myeloid leukemia (AML) with normal cytogenetics (CN-AML) and are associated with poor outcome. Using array-based comparative genome hybridization in pediatric CN-AML samples, we detected a WT1 deletion in one sample. The other WT1 allele was mutated. This prompted us to further investigate the role o...
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OBJECTIVE This study aimed to assess the prognostic impact of Wilms tumor 1 (WT1) mutations in cytogenetically normal acute myeloid leukemia (CN-AML) among Egyptian patients. MATERIALS AND METHODS Exons 1, 2, 3, 7, 8, and 9 of WT1 were screened for mutations in samples from 82 CN-AML patients out of 203 newly diagnosed AML patients, of age ranging from 21 to 74 years, using high-resolution ca...
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متن کاملWilms tumor 1 mutations in the pathogenesis of acute myeloid leukemia.
Wilms tumor 1 (WT1) has long been implicated in acute myeloid leukemia. It has been described to be both overexpressed and mutated in different forms of acute myeloid leukemia, and overexpression has been reported to play a prognostic role in this disease. However, the precise mechanism through which WT1 may play a role in leukemogenesis has remained elusive. In recent years, new evidence has e...
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ژورنال
عنوان ژورنال: Blood
سال: 2009
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood-2008-09-177949