Clinical Reasoning: Burning hands and feet

Neurological manifestations in chronic mountain sickness: the burning feet-burning hands syndrome.

OBJECTIVE To characterise the clinical features and nerve biopsy findings in patients with chronic mountain sickness (CMS) living in the Peruvian Andes, with particular attention to the occurrence of the "burning feet-burning hands" syndrome. METHODS Symptoms and signs were documented clinically in 10 patients with CMS and compared with those in five healthy subjects all living at 4338 metres...

The 'Burning-Feet' Syndrome

Autosomal dominant burning feet syndrome.

Familial burning feet syndrome inherited as an autosomal dominant trait has been described in only one family. Due to an associated sensory neuropathy the autosomal dominant burning feet syndrome was suggested to represent a variant form of hereditary sensory and autonomic neuropathy type I (HSAN I). Clinical, histopathological, and molecular genetic studies were performed in a large German kin...

Pantothenol and the burning feet syndrome.

Burning and aching of the extremities are often found in certain nutritional disorders of the nervous system and in diabetic neuropathy ; these symptoms always dominate the clinical picture of a peripheral neuropathy known as the burning feet syndrome. An excellent description of this syndrome was given by Smith & Woodruff (195 I) who observed several cases in malnourished persons in Japanese p...

The coevolution of human hands and feet.

Human hands and feet have longer, more robust first digits, and shorter lateral digits compared to African apes. These similarities are often assumed to be independently evolved adaptations for manipulative activities and bipedalism, respectively. However, hands and feet are serially homologous structures that share virtually identical developmental blueprints, raising the possibility that digi...