Clinical Pathophysiology of adult T-cell leukemia.
نویسندگان
چکیده
منابع مشابه
Specific cutaneous manifestations in adult T cell leukemia/lymphoma
Background and aim: Adult T cell leukemia/lymphoma (ATLL) is an aggresive malignancy which may occur in human T lymphotropic virus1(HTLV1) infected persons. HTLV1 is endemic in Khorasan with prevalence of 2.3% in general population. Since specific cutaneous manifestations of lymphoma may occur in a significant number of patients, we studied ATLL patients in Mashhad.Mate...
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Abstract Background: Adult T-cell leukemia/lymphoma (ATLL) is caused by human T-cell lymphotropic virus type-1 (HTLV-1). HTLV-1 oncogenes can induce malignancy through controlled gene expression of cell cycle checkpoints in the host cell. HTLV-I genes play a pivotal role in overriding cell cycle checkpoints and deregulate cellular division. In this study, we aimed to determine and comp...
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We screened serum samples from patients with various hematological disorders and healthy individuals for the presence of adult T-cell leukemia/lymphoma associated antigen (anti-ATLA) antibodies. These antibodies were detected not only in all patients with ATL but frequently in those diagnosed as T-cell malignant lymphoma or T-cell chronic lymphocytic leukemia; the positivity rate of anti-ATLA a...
متن کاملAdult T - Cell Leukemia : Clinical and Hem atologic Features of
Clinical and hematologic studies of 16 adult patients whose leukemic cells had Tcell markers are reported from Japan, where the incidence of various lymphoproliferative diseases differs considerably from that in Western countries. Leukemic cells were studied by cytotoxicity tests with specific antisera against human T (ATS) and B cells (ABS) in addition to the usual Tand B-cell markers (E roset...
متن کاملClinical Data of Eight Patients With Adult T - Cell Leukemia
The proliferative response of fresh peripheral blood loukemic cells from eight adult T cell leukemia (ATL) patients to interleukin-4 (11-4) was studied to determine the possibility that the 11-4-mediated T-ceIl growth pathway is involved in the cell growth of leukemic cells in ATL. Resting lymphocytes from ten normal individuals did not proliferate in response to ll-4. Leukemic cells from two A...
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ژورنال
عنوان ژورنال: The journal of the Japanese Society of Lymphoreticular Tissue research
سال: 1999
ISSN: 1883-681X,1342-9248
DOI: 10.3960/jslrt1997.39.11