Clinical outcomes of conversion to amyloid‐beta positivity in amyloid‐beta negative elderly

Background Early detection of amyloid beta (Aβ) accumulation has become important as Aβ begins before clinical symptoms appear. Previous longitudinal studies Aβ-negative (Aβ-) people have shown that some them convert to amyloid-positive (Aβ+) and others remain amyloid-negative. The effects conversion Aβ+ not been extensively investigated, yet. aim the study is investigate cognitive changes according Aβ+. Method We recruited subjects from 62 Korean Samsung Medical Center 275 Alzheimer’s Disease Neuroimaging Initiative database were followed for more than three years. All PET negative showed normal function at baseline. They years underwent dementia rating-sum boxes (CDR-SOB). Longitudinal cognition analyzed using a linear mixed effect model. Result Twelve (4.4%) Aβ- ADNI participants (4.8%) converted CDR-SOB was significantly deteriorated in converter group non-converter (p = 0.034 ADNI; p 0.022 Korean). Conclusion Our findings revealed predicted worse outcomes, suggesting it recognize potential candidates primary prevention AD.