Clinical Importance of c-Met Protein Expression in High Grade Astrocytic Tumors
نویسندگان
چکیده
منابع مشابه
An Immunohistochemical Study of Cyclin D1 Expression in Astrocytic Tumors and its Correlation with Tumor Grade
Background & Objective: Glioblastoma-multiforme is the high grade form of astrocytic tumors with a short survival time, which are the most common type of brain tumors. Therefore, finding new therapeutic options is essential. Cyclin D1 is expressed in some human malignancies and can be a potential target for therapeutic intervention. The aim of the present study was to determine...
متن کاملDetermination of CD117 Expression in Glial Tumors and Its Comparison between High Grade and Low Grade Tumors
Background and Objective: Gliomas are the most common primary brain tumors. Despite therapeutic advances, the majority of gliomas do not respond to either chemo or radiotherapy. CD117, the gene product of c-kit has been expressed in cells of glial tumors. Because gastrointestinal stromal tumors (GISTs) that express CD117 respond dramatically to treatment with tyrosine kinase inhibitors, ide...
متن کاملExpression and clinical significance of nestin in astrocytic tumors.
PURPOSE This study aimed to investigate the expression and clinical significance of nestin in human astrocytic tumors. METHODS Indirect immunofluorescent staining and flow cytometry were used to quantitatively detect the nestin content in 35 specimens, including 3 normal brain tissues, 29 astrocytic tumor (AT) tissues, and 3 peritumoral tissues. RESULTS In normal brain tissues, nestin expre...
متن کاملc-erbB-2 protein expression in astrocytic tumors of the brain
BACKGROUND Astrocytic tumors are the primary brain tumors, which often progress to glioblastoma, a highly malignant neoplasm of the central nervous system. There is much new data regarding to the formation and progression of these tumors; however, glioblastoma remains one of the most fatal neoplasms in humans. The aim of the study was to evaluate the role of c-erbB-2 protein expression in vario...
متن کاملClassification and grading of low-grade astrocytic tumors in children.
This article reviews current perspectives in the classification and grading of astrocytomas in children and calls attention to several histologically distinct groups of low-grade tumors that characteristically arise during childhood. Recognition of these tumors and the range of histological features that they may exhibit is essential for making rational assessments regarding their expected beha...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Neurologia medico-chirurgica
سال: 1998
ISSN: 0470-8105,1349-8029
DOI: 10.2176/nmc.38.851