Clinical Experience With U-500 Regular Insulin in Obese, Markedly Insulin-Resistant Type 2 Diabetic Patients
نویسندگان
چکیده
منابع مشابه
Clinical experience with U-500 regular insulin in obese, markedly insulin-resistant type 2 diabetic patients.
On a clinical basis, severe insulin resistance is defined as a situation in which a patient requires 200 units of insulin daily for 2 days (1). This definition was determined 50 years ago, when it was erroneously believed that the human pancreas secreted 200 units of insulin a day. Although it is now known that the normal pancreas secretes only 20–40 units of insulin a day, this clinical defini...
متن کاملU-500 Regular Insulin
OBJECTIVE To describe the clinical experience and the pharmacokinetics of U-500 regular insulin in severely insulin-resistant obese type 2 diabetic patients. RESEARCH DESIGN AND METHODS Patients requiring >200 units of insulin with A1C levels >8.0% were switched to U-500 regular insulin. For the pharmacokinetic study, fasting subjects received 100 units of U-500 regular insulin subcutaneously...
متن کاملPatient-reported outcomes in transition from high-dose U-100 insulin to human regular U-500 insulin in severely insulin-resistant patients with type 2 diabetes: analysis of a randomized clinical trial
BACKGROUND Initiation and titration of human regular U-500 insulin (U-500R) with a dosing algorithm of either thrice daily (TID) or twice daily (BID) improved glycemic control with fewer injections in patients with type 2 diabetes treated with high-dose, high-volume U-100 insulin. The objective of this analysis was to compare patient-reported outcomes between U-500R TID and BID treatment groups...
متن کاملStability of U-500 regular insulin in prefilled syringes.
OBJECTIVE To evaluate the stability of U-500 regular insulin in prefilled syringes stored under refrigeration for up to 28 days. METHODS U-500 regular insulin was drawn up in 1 mL insulin syringes in a clean, nonsterile environment to emulate conditions of a patient's home. Samples were assayed using a stability-indicating reverse-phase high-performance liquid chromatography method immediatel...
متن کاملInsulin U-500 in severe insulin resistance in type 2 diabetes mellitus.
Some patients with type 2 diabetes mellitus (T2DM) are profoundly insulin resistant and require large insulin doses to achieve optimal glycaemic control. However, large volumes of subcutaneous conventional U-100 insulin can cause discomfort at the injection site, resulting in poor concordance with insulin therapy. One therapeutic option is the use of U-500 insulin, thus reducing the insulin vol...
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ژورنال
عنوان ژورنال: Diabetes Care
سال: 2006
ISSN: 0149-5992,1935-5548
DOI: 10.2337/dc06-1478