Clinical Development of Biological Response Modifiers
نویسندگان
چکیده
منابع مشابه
Biological response modifiers.
Biological response modifiers (BRMs) of current clinical interest may be divided into two categories: immunomodulating agents and colony stimulating factors (CSFs). The first are employed to potentiate the host defences towards the tumor but results have proved disappointing in non-small cell lung cancer (NSCLC). With regard to the second, the real dose increment which may be ascribed to CSFs i...
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Immunotherapy is divided into two overlapping categories, active and passive. The goal of active immunotherapy is the stimulation of host ant ¡tumorimmunity, either cellular or hu moral. This can be accomplished in a direct or specific fashion by using tumor vaccines to generate an immune response to tumor-associated antigens. Nonspecific antitumor immunity can be propagated by compounds such ...
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Biological response modifiers improve the body's ability to fight cancer by immunostimulation. Although a century has passed since the first attempt was made to stimulate the host immune system against cancer, only the past decade has witnessed the scientific use of biological response modifiers. Recent advances in tumour immunology have enabled the development of specific agents targeted again...
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In recent years there has been a surge of interest in the treatment of chronic inflammatory disorders as a result of the development and application of targeted biological therapies. The elucidation of the overlapping cellular and cytokine immunopathology of such diverse conditions as rheumatoid arthritis (RA), Crohn's disease, and psoriasis points to specific targets for bioengineered proteins...
متن کاملClinical potential of biological response modifiers combined with chemotherapy for gastric cancer. Japanese experience.
The most effective treatment for gastric cancer is complete surgical resection with lymphadenectomy. However, a number of patients experience recurrence of the cancer even after curative surgery. This review focuses on comparative trials studying the use of adjuvant therapy with chemotherapy plus immunotherapy in the treatment of patients with curatively resected gastric cancer. Preoperative an...
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ژورنال
عنوان ژورنال: Canadian Journal of Infectious Diseases
سال: 1994
ISSN: 1180-2332
DOI: 10.1155/1994/583805