Clinical characteristics of COVID‐19 patients with hepatitis B virus infection — a retrospective study

Background & Aims The outbreak of coronavirus disease 2019 (COVID-19) has been declared a pandemic. Although COVID-19 is caused by infection in the respiratory tract, extrapulmonary manifestations including dysregulation immune system and hepatic injury have observed. Given high prevalence hepatitis B virus (HBV) China, we sought to study impact severe acute syndrome 2 (SARS-CoV-2) HBV coinfection patients. Methods Blood samples 50 SARS-CoV-2 coinfected patients, 56 mono-infected 57 HBeAg-negative chronic patient controls healthy admitted Renmin Hospital Wuhan University were collected this study. Complete blood count serum biochemistry panels markers indicative liver functions performed. Cytokines IFN-γ, TNF-α, IL-2, IL-4, IL-6 IL-10 evaluated. T cell, cell NK counts measured using flow cytometry. Results did not significantly affect outcome COVID-19. However, at onset COVID-19, patients showed more monocytopenia thrombocytopenia as well disturbed function albumin production lipid metabolism. Most disarrangement could be reversed after recovery from Conclusions While predispose outcomes, our data suggest poses higher extent host Thus, caution needs taken with management