Clinical bone marrow and blood stem cell transplantation
نویسندگان
چکیده
منابع مشابه
Advances in Hematopoietic Stem Cell Mobilization and Peripheral Blood Stem Cell Transplantation
Hematopoietic stem/progenitor cells (HSPCs) which give rise to different blood cell types are present within the bone marrow microenvironment, especially in flat bones such as skull, vertebrae, pelvis and chest. Interacting factors such as stromal derived factor-1/CXCR4, very late antigen-4/vascular cell adhesion molecule-1, Lymphocyte function-associated antigen-1/ intercellular adhesion molec...
متن کاملAllogeneic peripheral blood stem cell transplantation as an alternative to allogeneic bone marrow transplantation.
BMT, including 1) rapid hematopoietic engraftment, 2) less requirement for blood transfusion, antibiotic therapy and hospitalization days, and 3) avoidance of.risks and discomfort associated with general anesthesia for collecting hematopoietic stem cells (2). Taking these advantages into consideration, the use of PBSCwas applied for syngeneic and allogeneic transplantation in the early 1990' s....
متن کاملUpdate on Bone Marrow Collection and Stem Cell Transplantation
Bone marrow transplantation (BMT) is a powerful strategy for the treatment of leukemia, aplastic anemia, congenital immunodeficiency and autoimmune diseases. In humans, bone marrow cells (BMCs) have usually been collected by multiple bone marrow aspirations from the iliac crest. We have established a new “perfusion” method for collecting BMCs with minimal contamination with the peripheral blood...
متن کاملSystematic comparison of donor chimerism in peripheral blood and bone marrow after hematopoietic stem cell transplantation
Incomplete donor chimerism (DC) after hematopoietic stem cell transplantation (HSCT) is associated with reduced overall and disease-free survival and decreasing DC can precede overt relapse of malignant diseases. Sensitive chimerism quantification may therefore allow for early therapeutic intervention, potentially improving treatment response. Frequently, post-HSCT chimerism monitoring involves...
متن کاملBone Marrow GvHD after Allogeneic Hematopoietic Stem Cell Transplantation
The bone marrow is the origin of all hematopoietic lineages and an important homing site for memory cells of the adaptive immune system. It has recently emerged as a graft-versus-host disease (GvHD) target organ after allogeneic stem cell transplantation (alloHSCT), marked by depletion of both hematopoietic progenitors and niche-forming cells. Serious effects on the restoration of hematopoietic...
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ژورنال
عنوان ژورنال: Leukemia
سال: 2004
ISSN: 0887-6924,1476-5551
DOI: 10.1038/sj.leu.2403437