Clinical and Prognostic Values of DNMT3B Expression in Hepatocellular Carcinoma
نویسندگان
چکیده
DNA methyltransferase 3B (DNMT3B), one of methyltransferases has many roles in methylation and cancer pathogenesis. However, its clinical prognostic value was not studied hepatocellular carcinoma (HCC). In this study, we analyzed DNMT3B expression HCC by public big data, The Cancer Genome Atlas. Primary data about total 360 were downloaded clinicopathological implication analyzed. M stage (p = 0.07) pathologic 0.04) associated with expression, though did get a statistical significance. And alpha fetoprotein level positively correlated < 0.001). Higher predicted shorter overall survival patients 0.05). Disease-free lower within borderline significance 0.081). It suggested that may have an important role prognosis detail mechanism should be confirmed further. Keywords: Carcinoma, hepatocellular, DNMT3B, Methylation, Atlas
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ژورنال
عنوان ژورنال: Gyemyeong uidae haksulji
سال: 2022
ISSN: ['2092-8335', '2733-5380']
DOI: https://doi.org/10.46308/kmj.2022.00045