Clinical and Pathological Features of Mitochondrial DNA Deletion Disease Following Antiretroviral Treatment
نویسندگان
چکیده
منابع مشابه
Clinical and pathological features of mitochondrial DNA deletion disease following antiretroviral treatment.
Clinical and Pathological Features ofMitochondrial DNADeletion Disease Following Antiretroviral Treatment Certainnucleosideanalogreverse transcriptase inhibitor (NRTI) antiretroviral drugs used to treat human immunodeficiency virus (HIV) infection lead to accelerated accumulation of somaticmitochondrialDNA(mtDNA)mutations.1Theclinical significanceof thisobservation isunclearbutadelayed-onsetphe...
متن کاملClinical and Pathological Features of Iraqi Patients with Prostate Cancer
Background: The clinical pathological features were detected by measuring the prostatic acid phosphatase (PAP) activity according to the stages and grades of prostate cancer. We also explored the relationship between the disease and age with family history among the patients. Methods: Data were collected from direct interview and from the patient’s records. Blood samples that collected before ...
متن کاملliver mitochondrial dna copy number and deletion levels may contribute to nonalcoholic fatty liver disease susceptibility
results the relative expression of mtdna copy number was 3.7 fold higher in nafld patients than healthy controls (p < 0.0001). the results remained significant after adjustment for age, bmi, and gender (p = 0.02). in addition, the mtdna copy number was 4.3 (p < 0.0001) and 3.2-fold (p < 0.0001) higher in nonalcoholic fatty liver (nafl) and non-alcoholic steatohepatitis (nash) patients than heal...
متن کاملClinical implications and pathological associations of circulating mitochondrial DNA.
Mitochondria are membrane-enclosed organelles, the energy-producing centers in almost all eukaryotic cells. The evolutionary emergence of mitochondria is a result of the endocytosis of a-proteobacteria. There are several characteristic features which refer to its prokaryotic ancestors including its independent sets of double-stranded mitochondrial DNA, which is uniquely circular in form and con...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: JAMA Neurology
سال: 2015
ISSN: 2168-6149
DOI: 10.1001/jamaneurol.2015.0150