Click chemistry connections for functional discovery

In situ click chemistry: a powerful means for lead discovery.

Combinatorial chemistry and parallel synthesis are important and regularly applied tools for lead identification and optimisation, although they are often accompanied by challenges related to the efficiency of library synthesis and the purity of the compound library. In the last decade, novel means of lead discovery approaches have been investigated where the biological target is actively invol...

The growing impact of click chemistry on drug discovery.

Click chemistry is a modular approach that uses only the most practical and reliable chemical transformations. Its applications are increasingly found in all aspects of drug discovery, ranging from lead finding through combinatorial chemistry and target-templated in situ chemistry, to proteomics and DNA research, using bioconjugation reactions. The copper-(I)-catalyzed 1,2,3-triazole formation ...

Functional Polymer Gels by Click- and Supramolecular Chemistry

A versatile "click" chemistry precursor of functional polystyrene nanoparticles.

Functional nanoparticles (NPs) are becoming important building blocks in the emerging fi elds of nanomedicine, nanolithography and nanoelectronics, among others. [ 1 ] Several unexpected nanoscale effects have been discovered for these new materials in recent years. [ 2–4 ] Useful synthetic routes to single-molecule polymeric NPs in the 2–15 nm size range with well-defi ned arrangement of funct...

Click chemistry with DNAw