CLEC5A (MDL-1) is a novel PU.1 transcriptional target during myeloid differentiation
نویسندگان
چکیده
منابع مشابه
Transcriptional regulation of myeloid differentiation primary response (MyD) genes during myeloid differentiation is mediated by nuclear factor Y.
To understand the molecular mechanism by which interleukin-6 (IL-6) regulates myeloid differentiation primary response (MyD) genes at the onset of M1 myeloid differentiation, we used JunB as a representative MyD gene to isolate and characterize IL-6 responsive elements. An IL-6 responsive element was localized between -65 and -52 of the JunB promoter (-65/-52 IL-6RE). By using antibody and olig...
متن کاملA novel interferon-inducible gene expressed during myeloid differentiation.
The acute promyelocytic leukemia cell line, NB4, can be induced to differentiate to mature granulocytes by retinoic acid treatment. A novel retinoic acid-inducible cDNA clone, designated RI58, was isolated from a cDNA library constructed from retinoic acid-treated NB4 cells by differential hybridization. RI58 cDNA encodes a protein of 58kDa which has a similarity in its amino acids sequence to ...
متن کاملA novel, myeloid transcription factor, C/EBP epsilon, is upregulated during granulocytic, but not monocytic, differentiation.
Human C/EBP epsilon is a newly cloned CCAAT/enhancer-binding transcription factor. Initial studies indicated it may be an important regulator of human myelopoiesis. To elucidate the range of expression of C/EBP epsilon, we used reverse transcription-polymerase chain reaction (RT-PCR) analysis and examined its expression in 28 hematopoietic and 14 nonhematopoietic cell lines, 16 fresh myeloid le...
متن کاملId-1 is a key transcriptional regulator of glioblastoma aggressiveness and a novel therapeutic target.
Glioblastoma is the most common form of primary adult brain tumors. A majority of glioblastomas grow invasively into distant brain tissue, leading to tumor recurrence, which is ultimately incurable. It is, therefore, essential to discover master regulators that control glioblastoma invasiveness and target them therapeutically. We show here that the transcriptional regulator Id-1 plays a critica...
متن کاملConcomitant transcriptional and post-transcriptional control of mRNA abundance during human myeloid cell differentiation.
The mechanisms controlling the expression of two genes during the differentiation of HL60 cells have been studied. The relative abundance of one mRNA, designated 2B5, increases during retinoic acid-induced differentiation; this increase can be accounted for, in part at least, by a marked increase in the rate of transcription of the gene. The relative abundance of the second, pCG56, decreases du...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Molecular Immunology
سال: 2011
ISSN: 0161-5890
DOI: 10.1016/j.molimm.2010.10.016