Cleavage of vasoactive intestinal peptide at multiple sites by autoantibodies
نویسندگان
چکیده
منابع مشابه
Stabilization of vasoactive intestinal peptide by lipids.
An anionic phospholipid, phosphatidylglycerol (PG), induced vasoactive intestinal peptide (VIP) to adopt a helical conformation, determined by circular dichroism studies. PG inhibited the trypsin-catalyzed, antibody-catalyzed and uncatalyzed cleavage of VIP, measured by radiometric and HPLC methods. Phosphatidylcholine, a neutral lipid, did not alter the circular dichroism spectra of VIP, and i...
متن کاملRat Cerebellar Grafts Have 125I-Vasoactive Intestinal Peptide Binding Sites
Neuropeptides and their receptors may play a role in the growth and/or differentiation of fetal brain transplants. Previously, we found that gas-trin releasing peptide (GRP) receptors develop on fetal cortex grafts transplanted into the adult rat cortex, spinal cord or 4th ventricle/1,2/. Here we investigated the presence of vasoactive intestinal peptide (VIP) receptors in rat fetal brain trans...
متن کاملVasoactive intestinal peptide (VIP).
In 1969, Said and Mutt reported the extraction from secretion, increased flow of alkaline pancreatic normal lung tissue of a peptide which was capable juice and small intestinal juice with increased cyclic of causing gradual but prolonged peripheral AMP content (Makhlouf and Said, 1975), overlap vasodilation. This finding led them to search for markedly with the actions of the other three pepti...
متن کاملPrevention of experimental autoimmune uveoretinitis by vasoactive intestinal peptide.
BACKGROUND Vasoactive intestinal peptide (VIP), a neuropeptide that is known to be present in lymphoid tissue microenvironments, shows prominent anti-inflammatory actions. OBJECTIVE To examine the potential effect of VIP on the development of experimental autoimmune uveoretinitis (EAU). DESIGN We immunized C57BL/6 mice with human interphotoreceptor retinoid-binding protein peptide 1-20 (h-I...
متن کاملPulmonary clearance of vasoactive intestinal peptide.
Vasoactive intestinal peptide causes bronchodilatation when given intravenously but is less effective in both animals and man when given by inhalation. This difference may be due to poor transit of the peptide across the bronchial epithelium. To test this hypothesis pulmonary clearance of radiolabelled vasoactive intestinal peptide was measured in Sprague Dawley rats and compared with that of p...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1991
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)98525-x