Clearing the Lens

The Inhibition of Lipemia-clearing

It was recently shown in this laboratory (1) that in idiopathic hyperlipemia the elimination of lipids from the blood stream following an intravenous infusion of a fat emulsion is considerably delayed, indicating a defect of the lipemiaclearing mechanism in these patients. It was then found that the clearing activity present in the serum of normal human subjects who have received heparin was in...

Clearing the Brain's Amyloid Cobwebs

Elevated cerebral levels of amyloid beta-protein occur universally in Alzheimer's disease, yet only a few patients show evidence of increased Abeta production. Therefore, defects in proteases that degrade Abeta could underlie some or many cases of familial and sporadic AD. This previously neglected topic has begun receiving serious attention. Understanding how proteolysis regulates Abeta levels...

Chromatin transcription: Clearing the gridlock

A factor has been purified that specifically facilitates RNA chain elongation in a chromatin context; the properties of this factor help to define the challenges that lie ahead in understanding how RNA polymerase manages to transcribe DNA that is packaged into chromatin.

Clearing the way to implantation.

The endocrine symphony known as the reproductive life cycle consists of a complex series of hormonally driven “movements.” The sole rationale for the reproductive cycle is the generation of a fertilizable ovum and, contingent upon fertilization, the establishment of implantation and of an ongoing gestation. Although fecundity rates vary among species, there can be little question as to the ongo...

Clearing the smoke or muddying the water?