Clathrin’s muscle-building regimen

Clathrin’s muscle-building regimen

C lathrin is best known for its role in endocytosis and other membrane traffi cking events, but the protein's heavy chain has several additional functions , including organization of mitotic spindles and coordination of actin fi laments at intercellular adhesions. Vassilopoulos et al. now reveal that the clathrin heavy chain (CHC) also helps to organize skeletal muscle sarcomeres by promoting t...

The medication regimen review: building rapport with the consultant pharmacist.

Building muscle: molecular regulation of myogenesis.

The genesis of skeletal muscle during embryonic development and postnatal life serves as a paradigm for stem and progenitor cell maintenance, lineage specification, and terminal differentiation. An elaborate interplay of extrinsic and intrinsic regulatory mechanisms controls myogenesis at all stages of development. Many aspects of adult myogenesis resemble or reiterate embryonic morphogenetic e...

CHC22 and CHC17 clathrins have distinct biochemical properties and display differential regulation and function

Clathrins are cytoplasmic proteins that play essential roles in endocytosis and other membrane traffic pathways. Upon recruitment to intracellular membranes, the canonical clathrin triskelion assembles into a polyhedral protein coat that facilitates vesicle formation and captures cargo molecules for transport. The triskelion is formed by trimerization of three clathrin heavy-chain subunits. Mos...

Building a robotic link between muscle dynamics and hydrodynamics.

This study used a novel feedback approach to control a robotic foot using force and length signals transmitted from an isolated Xenopus laevis frog muscle. The foot's environment (inertial versus hydrodynamic), gearing (outlever/inlever) and size were changed to alter the muscle's load. Upon nerve stimulation (250 Hz, 80 ms train duration), variation in loading generated a range of muscle stres...