منابع مشابه
COP and clathrin-coated vesicle budding: different pathways, common approaches.
Vesicle and tubule transport containers move proteins and lipids from one membrane system to another. Newly forming transport containers frequently have electron-dense coats. Coats coordinate the accumulation of cargo and sculpt the membrane. Recent advances have shown that components of both COP1 and clathrin-adaptor coats share the same structure and the same motif-based cargo recognition and...
متن کاملThe synaptic vesicle cycle: a single vesicle budding step involving clathrin and dynamin
Strong evidence implicates clathrin-coated vesicles and endosome-like vacuoles in the reformation of synaptic vesicles after exocytosis, and it is generally assumed that these vacuoles represent a traffic station downstream from clathrin-coated vesicles. To gain insight into the mechanisms of synaptic vesicle budding from endosome-like intermediates, lysed nerve terminals and nerve terminal mem...
متن کاملAn endophilin-dynamin complex promotes budding of clathrin-coated vesicles during synaptic vesicle recycling.
Clathrin-mediated vesicle recycling in synapses is maintained by a unique set of endocytic proteins and interactions. We show that endophilin localizes in the vesicle pool at rest and in spirals at the necks of clathrin-coated pits (CCPs) during activity in lamprey synapses. Endophilin and dynamin colocalize at the base of the clathrin coat. Protein spirals composed of these proteins on lipid t...
متن کاملStructure of the PTEN-like region of auxilin, a detector of clathrin-coated vesicle budding.
Auxilin, a J-domain containing protein, recruits the Hsc70 uncoating ATPase to newly budded clathrin-coated vesicles. The timing of auxilin arrival determines that uncoating will commence only after the clathrin lattice has fully assembled and after membrane fission is complete. Auxilin has a region resembling PTEN, a PI3P phosphatase. We have determined the crystal structure of this region of ...
متن کاملA Primer on Vesicle Budding
How do vesicular coats form on the donor membrane? Sebastian Springer,* Anne Spang,* and Randy Schekman*†‡ Do cargo proteins influence this process? Recent work *Department of Molecular and Cell Biology and on the exchange of proteins between the endoplasmic †Howard Hughes Medical Institute reticulum (ER) and the Golgi apparatus in SaccharoUniversity of California myces cerevisiae and higher eu...
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ژورنال
عنوان ژورنال: Reactome - a curated knowledgebase of biological pathways
سال: 2009
ISSN: 1934-1792
DOI: 10.3180/react_19187.1