Clastogenic Potential Testing of Some Hair Dye Components by the Bone Marrow Micronucleus Analysis.
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چکیده
منابع مشابه
The Role of Bone Marrow Aspiration and Bone Marrow Biopsy in Diagnosis of Bone Marrow Metastases
Background: Bone marrow is the site of many malignant disorders and it is one of the common places for solid tumors to metastasize. Examination of the bone marrow aspirate and biopsy is a routine procedure performed for assessment of various conditions such as cytopenias, hematologic neoplasms, nonmalignant disorders and metastatic neoplasms. Methods: The patients were referred to the Hema...
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Ruta graveolens belonging to family Rutaceae has long been traditionally used as a medicinal plant as well as a flavoring agent in food. However, very little data are available on the toxicity of the plant. This report presents evidence on the genotoxic and clastogenic potential of an extract of Ruta graveolens and Ruta 200C, a homeopathic preparation. Various types of chromosomal aberrations w...
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Although most of the vaccines are prepared out of the heat killed or attenuated virus and bacteria, study on their genotoxicity/clastogenicity is meagre. Therefore, the clastogenic potential of certain widely used vaccines namely, measles, rubella and rabies (rabipur), has been assessed at 24 h post-treatment from mouse bone marrow cells after a low dose, single intraperitoneal treatment. Mitot...
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The frequency of micronuclei in bone marrow cells of mice treated or not with Liv. 52 and then exposed to 4.5 Gy of gamma-radiation was evaluated from 6 h to 14 days post irradiation. The frequency of micronuclei increased from 6 h to 24 h post irradiated in both irradiated groups and declined thereafter, the frequency of micronuclei remaining significantly lower in the Liv. 52-treated group. T...
متن کاملMutagenicity testing with transgenic mice. Part I: Comparison with the mouse bone marrow micronucleus test
As part of a larger literature study on transgenic animals in mutagenicity testing, test results from the transgenic mutagenicity assays (lacI model; commercially available as the Big Blue(R) mouse, and the lacZ model; commercially available as the Mutatrade markMouse), were compared with the results on the same substances in the more traditional mouse bone marrow micronucleus test. 39 substanc...
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ژورنال
عنوان ژورنال: CYTOLOGIA
سال: 1992
ISSN: 0011-4545,1348-7019
DOI: 10.1508/cytologia.57.149