Classification and Secondary Metabolite-Biosynthetic Gene Clusters of Marine Streptomyces Strains Including a Lobophorin- and Divergolide-Producer

Two Streptomyces strains, named N11-26 and DC10-5, were isolated from deep-sea non-photosynthetic stony coral, respectively. Strain produces lobophorin C divergolides, which are antimicrobial substances. This study aimed to classify these strains reveal their cryptic potential synthesize other secondary metabolites, such as polyketides nonribosomal peptides. Strains DC10-5 showed 16S rRNA gene sequence similarities of 100% 99.9% olivaceus NRRL B-3009T, By digital DNA–DNA hybridization using whole-genome sequences, classified olivaceus. was closer the type strain S. than possessed 17 clusters polyketide synthase (PKS) and/or peptide synthetases (NRPS) genes, whereas harbored 19 clusters. Putative products by predicted bioinformatic analyses. Although 15 conserved between two four specific in represents a diversity compounds To best our knowledge, this is first report annotating all PKS NRPS with putative provide useful information for genome mining.