Cladribine for people with multiple sclerosis
نویسندگان
چکیده
منابع مشابه
Cladribine in aggressive forms of multiple sclerosis.
Cladribine (2-chlorodeoxyadenosine) is an immunosuppressant drug previously evaluated in multiple sclerosis (MS) with variable results. We report six patients with aggressive relapsing MS who despite a poor response to other therapies had a favourable clinical evolution after cladribine. Four women and two men with a rapid increase in the number and severity of relapses leading to increasing di...
متن کاملCladribine in the treatment of multiple sclerosis
ISSN 2041-6792 10.4155/CLI.10.32 © 2011 Future Science Ltd Treatment with cladribine leads to a preferential and sustained reduction in lymphocytes and monocytes, resulting in long-lasting depletion of CD4+ and CD8+ T cells. In the Phase III placebo-controlled trial in relapsing–remitting multiple sclerosis (the CLARITY study), oral cladribine at 96 weeks significantly reduced annual relapse ra...
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PURPOSE The aims of this study were to characterize the concentration-time course of cladribine (CdA) and its main metabolite 2-chloroadenine (CAde), estimate interindividual variability in pharmacokinetics (PK), and identify covariates explaining variability in the PK of CdA. METHODS This population PK analysis was based on the combined dataset from four clinical studies in patients with mul...
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Background. Multiple Sclerosis (MS) is an autoimmune, inflammatory, and chronic disease which, under the effect of the wastes of myelin degradation occurs in the white matter of the brain, spinal cord, and visual nerves. The main complications of this disease are fatigue, muscle cramps, tremor, imbalance, and walking imbalance. Objectives. The purpose of this study is to investigate the spine ...
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Objectives: Leisure is a domain of life that is very important, particularly for people with neurological disorders. However, due to social and cultural differences, leisure activities have not been studied extensively. The aim of this study is to determine the different factors influencing leisure activities among people afflicted with Multiple Sclerosis (MS) within the framework of Iranian cu...
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ژورنال
عنوان ژورنال: Cochrane Database of Systematic Reviews
سال: 2020
ISSN: 1465-1858
DOI: 10.1002/14651858.cd013524