Citrus, Milk Thistle, and Propolis Extracts Improved the Intestinal Permeability of Curcuminoids from Turmeric Extract─ an <i>In Silico</i> and <i>In Vitro</i> Permeability Caco-2 Cells Approach

Curcumin has been traditionally used in food recipes for biological health benefits. However, these properties are compromised due to its very low bioavailability. Thus, this work assessed the impact of using natural potential bioenhancers improve intestinal permeability and understanding interaction flavonoids with curcuminoids through molecular dynamic simulation. The (Papp) was measured on human colon carcinoma cell line (Caco-2). Papp values Caco-2 monolayers provided information regarding increased curcumin across barrier specially caused by presence citrus (100.45%), milk thistle extracts (81.70%) at level +1 showed higher increase (%) compared 0. With respect soft standardized green propolis EPP-AF extract, 0 (26.34%). Molecular (MD) simulations naringin silybin B confirmed concentrations non-covalent interactions. These results suggest prominent importance association as bioavailability