Citrinin Derivatives From Penicillium Citrinum Y34 That Inhibit ?-Glucosidase and ATP-Citrate Lyase
نویسندگان
چکیده
Two new citrinin dimers bearing a 6,6-spiroketal moiety (1 and 2) four known analogues (3–6), together with 18 monomers (7–24), were isolated from the culture of hydrothermal vent-associated fungus Penicillium citrinum Y34. Their structures identified by extensive spectroscopic analyses, 13 C NMR calculation in combination DP4+, linear correlation coefficient ( R 2 ), mean absolute error (MAE) values electronic circular dichroism (ECD) calculation. The ? -glucosidase ATP-citrate lyase (ACL) inhibitory activities compounds evaluated. Compounds 1, 3, 12 displayed moderate IC 50 239.8, 176.2, 424.4 ?M, respectively. Enzyme kinetics investigations 1 3 suggested their non-competitive inhibition K i 204.3 212.7 Meanwhile, compound 4 showed significant ACL potential an value 17.4 ?M. Furthermore, interactions investigated molecular docking assay. This study demonstrates that citrinins, especially for dimers, could be lead development agents treatment metabolic diseases.
منابع مشابه
Citrinin derivatives from the marine-derived fungus Penicillium citrinum.
Three new citrinin derivatives, penicitrinols C, D, and E (1-3), along with two known compounds, citrinin (4) and decarboxydihydrocitrinone (5), were isolated from Penicillium citrinum. Their structures were determined by spectroscopic methods and X-ray diffraction analysis. Compounds 1 and 3 demonstrated weak cytotoxicity against the HL-60 cell line.
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Other names: ACL, ATPCL, CLATP HGNC (Hugo): ACLY Location: 17q21.2 Note Note that the International Union for Biochemistry and Molecular Biology (IUBMB)'s enzyme nomenclature accepts ATP citrate synthase as the name for ACLY's encoded protein (EC 2.3.3.8). However, ATP citrate lyase is more commonly used and other names include citrate cleavage enzyme, ATP-citrate (pro-S)-lyase, ATPCL, CLATP. A...
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ژورنال
عنوان ژورنال: Frontiers in Marine Science
سال: 2022
ISSN: ['2296-7745']
DOI: https://doi.org/10.3389/fmars.2022.961356