منابع مشابه
Regulation of citric acid cycle by calcium.
The relationship of extramitochondrial Ca2+ to intramitochondrial Ca2+ and the influence of intramitochondrial free Ca2+ concentrations on various steps of the citric acid cycle were evaluated. Ca2+ was measured using the Ca2+ sensitive fluorescent dye fura-2 trapped inside the rat heart mitochondria. The rate of utilization of specific substrates and the rate of accumulation of citric acid cyc...
متن کاملCitric acid cycle intermediates in cardioprotection.
Over the last decade, there has been a concerted clinical effort to deliver on the laboratory promise that a variety of maneuvers can profoundly increase cardiac tolerance to ischemia and/or reduce additional damage consequent upon reperfusion. Here we will review the proximity of the metabolic approach to clinical practice. Specifically, we will focus on how the citric acid cycle is involved i...
متن کاملMetabolomics and Gene Expression Analysis Reveal Down-regulation of the Citric Acid (TCA) Cycle in Non-diabetic CKD Patients
Chronic kidney disease (CKD) is a public health problem with very high prevalence and mortality. Yet, there is a paucity of effective treatment options, partly due to insufficient knowledge of underlying pathophysiology. We combined metabolomics (GCMS) with kidney gene expression studies to identify metabolic pathways that are altered in adults with non-diabetic stage 3-4 CKD versus healthy adu...
متن کاملImpaired Citric Acid Cycle in Nondiabetic Chronic Kidney Disease
Chronic kidney disease (CKD) influencesmore than 10% of adult population worldwide (Hill et al., 2016). Among this population, many of them could progress into the end stage renal disease and finally require the therapies of kidney transplantation or dialysis. Thus, it is of vital importance in retarding the progression of CKDs during the early stage (stages 1–2) via an effective intervention. ...
متن کاملDevelopmental block in citric acid cycle mutants of Bacillus subtilis.
Mutants deficient in different enzymes of the citric acid cycle can be subdivided into two groups according to the frequency at which they produce heat-resistant spores in nutrient sporulation medium. However, the majority of cells can develop in this medium only to the axial filament stage I of sporulation; aconitase and isocitrate dehydrogenase mutants need the addition of glutamate to reach ...
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ژورنال
عنوان ژورنال: Reactome - a curated knowledgebase of biological pathways
سال: 2002
ISSN: 1934-1792
DOI: 10.3180/1785.1