Circulating n-3 fatty acids and trans-fatty acids, PLA2G2A gene variation and sudden cardiac arrest
نویسندگان
چکیده
منابع مشابه
Circulating n-3 fatty acids and trans-fatty acids, PLA2G2A gene variation and sudden cardiac arrest.
Whether genetic factors influence the associations of fatty acids with the risk of sudden cardiac arrest (SCA) is largely unknown. To investigate possible gene-fatty acid interactions on SCA risk, we used a case-only approach and measured fatty acids in erythrocyte samples from 1869 SCA cases in a population-based repository with genetic data. We selected 191 SNP in ENCODE-identified regulatory...
متن کاملn-3 fatty acids prevent whereas trans-fatty acids induce vascular inflammation and sudden cardiac death.
n-3 PUFA have well-recognised cardio-beneficial effects. In contrast, premature coronary deaths are associated with consumption of high levels of trans-fatty acids (TFA). The present study determined the effects of n-3 PUFA and TFA on sudden cardiac death and vascular inflammation. A rat coronary ligation model was used to study the effect of fatty acids on sudden cardiac death, whereas a mouse...
متن کاملTrans-fatty acids and sudden cardiac death.
Sudden cardiac death (SCD) is usually due to ventricular fibrillation and can occur as a first manifestation of heart disease. Prevention of ventricular fibrillation and SCD with n-3 polyunsaturated fatty acids is well documented. Trans-fatty acids (TFA) in the diet and cell membranes might affect the risk of SCD as well. We review evidence from an observational study that high levels of trans-...
متن کاملn-3 fatty acids and the risk of sudden death.
BACKGROUND Experimental data suggest that long-chain n-3 polyunsaturated fatty acids found in fish have antiarrhythmic properties, and a randomized trial suggested that dietary supplements of n-3 fatty acids may reduce the risk of sudden death among survivors of myocardial infarction. Whether long-chain n-3 fatty acids are also associated with the risk of sudden death in those without a history...
متن کاملTrans Fatty Acids
What are trans fatty acids (TFA)? Fatty acids found in foods can be saturated (SFA, no double bonds), monounsaturated (MUFA, 1 double bond) or polyunsaturated (PUFA , 2 or more double bonds). The double bonds provide rigidity to the molecule and result in specific molecular configurations. Naturally occurring fatty acids in foods usually have the cis configuration, i.e. the hydrogen atoms with ...
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ژورنال
عنوان ژورنال: Journal of Nutritional Science
سال: 2016
ISSN: 2048-6790
DOI: 10.1017/jns.2016.2