Circadian variation and triggering of cardiovascular events

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Disruption of normal circadian rhythms and cardiovascular events

The intrinsic properties of the heart and the vascular tree exhibit marked oscillations over 24 h. Diurnal variations in the response of the cardiovascular system to environmental stimuli are mediated by the complex interplay of extracellular (ie, neurohumoral factors) and intracellular (ie, circadian clock) influences. The intracellular circadian clock comprises a series of transcriptional mod...

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Circadian variation and triggers of onset of acute cardiovascular disease.

Information obtained during the past decade suggests the need to reexamine the possibility that the onset of myocardial infarction and sudden cardiac death is frequently triggered by daily activities. The importance of physical or mental stress in triggering onset of coronary thrombosis is supported by the findings that 1) the frequencies of onset of myocardial infarction, sudden cardiac death,...

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Circadian variation in ischemic threshold. A mechanism underlying the circadian variation in ischemic events.

BACKGROUND There is a circadian pattern in the occurrence of cardiac events in patients with coronary artery disease. Whether changes in coronary vascular tone contribute to these phenomena is unknown. We measured the ischemic threshold, defined as either the heart rate or rate-pressure product at 1-mm ST segment depression during treadmill exercise and used it as an index of the lowest coronar...

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A Mechanism Underlying the Circadian Variation in Ischemic Events

Background. There is a circadian pattern in the occurrence of cardiac events in patients with coronary artery disease. Whether changes in coronary vascular tone contribute to these phenomena is unknown. We measured the ischemic threshold, defined as either the heart rate or rate-pressure product at 1-mm ST segment depression during treadmill exercise and used it as an index of the lowest corona...

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Emotional triggering of cardiac events.

Psychological factors may contribute not only to the evolution of coronary atherosclerosis and long-term risk of coronary heart disease, but also to the triggering of acute cardiac events in patients with advanced atherosclerosis. Evidence for emotional triggering of cardiac events derives both from population-based studies of hospital admissions and sudden deaths following major traumas such a...

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ژورنال

عنوان ژورنال: Vascular Medicine

سال: 1999

ISSN: 1358-863X,1477-0377

DOI: 10.1177/1358836x9900400108