Circadian Proteins and Genotoxic Stress Response
نویسندگان
چکیده
منابع مشابه
Circadian Proteins and Genotoxic Stress Circadian Clocks and the Transcriptome Functions of the Cardiomyocyte Circadian Clock Circadian Clocks and Vascular Function Molecular Clocks and Cardiometabolic Syndrome
The circadian clock is an evolutionarily conserved time-keeping system that coordinates the physiology of the organism with daily changes in the environment. A growing body of evidence gradually leads to the conception that virtually all aspects of the biochemical, physiological, and behavioral functions of the animal are linked to circadian regulation. Moreover, proper synchronization of vario...
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Both p53 and ceramide have been implicated in the regulation of growth suppression. p53 has been proposed as the "guardian of the genome" and ceramide has been suggested as a "tumor suppressor lipid. " Both molecules appear to regulate cell cycle arrest, senescence, and apoptosis. In this study, we investigated the relationship between p53 and ceramide. We found that treatment of Molt-4 cells w...
متن کاملMolecular Time: An Often Overlooked Dimension to Cardiovascular Disease [2009;105:1047–1061] Circadian Proteins and Genotoxic Stress Circadian Clocks and the Transcriptome Functions of the Cardiomyocyte Circadian Clock Circadian Clocks and Vascular Function Molecular Clocks and Cardiometabolic Syndrome
The circadian clock is an evolutionarily conserved time-keeping system that coordinates the physiology of the organism with daily changes in the environment. A growing body of evidence gradually leads to the conception that virtually all aspects of the biochemical, physiological, and behavioral functions of the animal are linked to circadian regulation. Moreover, proper synchronization of vario...
متن کاملMolecular Time: An Often Overlooked Dimension to Cardiovascular Disease Circadian Clocks and The Transcriptome Functions of The Cardiomyocyte Circadian Clock Circadian Clocks and Vascular Function Molecular Clocks and Cardiometabolic Syndrome Circadian Proteins and Genotoxic Stress
Diurnal rhythms influence cardiovascular physiology such as heart rate and blood pressure and the incidence of adverse cardiac events such as heart attack and stroke. For example, shift workers and patients with sleep disturbances, such as obstructive sleep apnea, have an increased risk of heart attack, stroke, and sudden death. Diurnal variation is also evident at the molecular level, as gene ...
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Ribonucleotide reductase (RNR) is an essential enzyme that provides dNTPs for DNA replication and repair. Arabidopsis (Arabidopsis thaliana) encodes three AtRNR2-like catalytic subunit genes (AtTSO2, AtRNR2A, and AtRNR2B). However, it is currently unclear what role, if any, each gene contributes to the DNA damage response, and in particular how each gene is transcriptionally regulated in respon...
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ژورنال
عنوان ژورنال: Circulation Research
سال: 2010
ISSN: 0009-7330,1524-4571
DOI: 10.1161/circresaha.109.207076