Ciliary subcompartments: how are they established and what are their functions?

Ciliary subcompartments: how are they established and what are their functions?

Cilia are conserved subcellular organelles with diverse sensory and developmental roles. Recently, they have emerged as crucial organelles whose dysfunction causes a wide spectrum of disorders called ciliopathies. Recent studies on the pathological mechanisms underlying ciliopathies showed that the ciliary compartment is further divided into subdomains with specific roles in the biogenesis, mai...

Nanorattles or yolk-shell nanoparticles--what are they, how are they made, and what are they good for?

The development of nanotechnology has led to the design of cutting-edge nanomaterials with increasing levels of complexity. Although "traditional" solid, uniform nanoparticles are still the most frequently reported structures, new generations of nanoparticles have been constantly emerging over the last several decades. The outcome of this nano-art extends beyond nanomaterials with alternative c...

Moisturizers: what they are and how they work.

Moisturizers are widely used in various dermatologic and cosmetic skin therapies. Different classes of moisturizers are based on their mechanism of action, including occlusives, humectants, emollients and protein rejuvenators. Commercially available moisturizers often utilize components of each of these classes to provide their beneficial effect. Dry skin (xerosis) is the major indication of us...

Understanding Herbicides: What They are and How They Work

Bayes Factors: What They Are and What They Are Not

Bayes factors have been ooered by Bayesians as alternatives to P-values (or significance probabilities) for testing hypotheses and for quantifying the degree to which observed data support or connict with a hypothesis. Schervish (1996) showed how the interpretation of P-values as measures of support suuers a certain logical aw. In this paper, we show how Bayes factors suuer that same aw. We inv...