Ciliary Extracellular Vesicles: Txt Msg Organelles
نویسندگان
چکیده
منابع مشابه
Scanning microscopy of ciliary organelles
Cilia and flagella are characteristic cellular appendages widely present in diverse animal phyla, as well as in some algae; motility of these organelles results from interactions within a rather organized array of axial microtubules, well known as the “9+2 complex”. High resolution transmission electron microscopy studies of different cilia, along with data of physical parameters, biochemistry,...
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Signaling receptors dynamically exit cilia upon activation of signaling pathways such as Hedgehog. Here, we find that when activated G protein-coupled receptors (GPCRs) fail to undergo BBSome-mediated retrieval from cilia back into the cell, these GPCRs concentrate into membranous buds at the tips of cilia before release into extracellular vesicles named ectosomes. Unexpectedly, actin and the a...
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ژورنال
عنوان ژورنال: Cellular and Molecular Neurobiology
سال: 2016
ISSN: 0272-4340,1573-6830
DOI: 10.1007/s10571-016-0345-4