Cilia and cilia-associated proteins in cancer
نویسندگان
چکیده
منابع مشابه
A "so cilia" network: cilia proteins start "social" networking.
Cilia are unique cellular organelles found in nearly all cell types. In recent years, the importance of these organelles has been highlighted by the discovery that mutations in genes encoding proteins related to cilia biogenesis and function cause a class of complex syndromes termed ciliopathies. Emerging evidence suggests interactions among the various ciliopathy-associated proteins, but the p...
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In most vertebrates, mitotic spindles and primary cilia arise from a common origin, the centrosome. In non-cycling cells, the centrosome is the template for primary cilia assembly and, thus, is crucial for their associated sensory and signaling functions. During mitosis, the duplicated centrosomes mature into spindle poles, which orchestrate mitotic spindle assembly, chromosome segregation, and...
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BACKGROUND Whereas cilia damage and reduced cilia beat frequency have been implicated as causative of reduced mucociliary clearance in smokers, theoretically mucociliary clearance could also be affected by cilia length. Based on models of mucociliary clearance predicting that cilia length must exceed the 6-7 microm airway surface fluid depth to generate force in the mucus layer, we hypothesized...
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In Eukaryotes, except fungi and higher plants, the coordinated beating of the motile cilia propels unicellular organisms and regulate the flow of the extracellular fluids in multicellular life forms. In humans proper beating of these tiny nanomachines ensures removal of the mucus and bacteria out of the airways, circulation of cerebrospinal fluid in brain ventricles, transport of the oocytes in...
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ژورنال
عنوان ژورنال: Drug Discovery Today: Disease Mechanisms
سال: 2013
ISSN: 1740-6765
DOI: 10.1016/j.ddmec.2013.03.004