Cilastatin Attenuates Cisplatin-Induced Proximal Tubular Cell Damage
نویسندگان
چکیده
منابع مشابه
Cilastatin attenuates cisplatin-induced proximal tubular cell damage.
A major area in cancer therapy is the search for protective strategies against cisplatin-induced nephrotoxicity. We investigated the protective effect of cilastatin on cisplatin-induced injury to renal proximal tubular cells. Cilastatin is a specific inhibitor of renal dehydrodipeptidase I (DHP-I), which prevents hydrolysis of imipenem and its accumulation in the proximal tubule. Primary cultur...
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[This corrects the article on p. 1701 in vol. 8, PMID: 26203260.].
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ژورنال
عنوان ژورنال: Journal of Pharmacology and Experimental Therapeutics
سال: 2010
ISSN: 0022-3565,1521-0103
DOI: 10.1124/jpet.110.165779