منابع مشابه
Genomic Transition to Pathogenicity in Chytrid Fungi
Understanding the molecular mechanisms of pathogen emergence is central to mitigating the impacts of novel infectious disease agents. The chytrid fungus Batrachochytrium dendrobatidis (Bd) is an emerging pathogen of amphibians that has been implicated in amphibian declines worldwide. Bd is the only member of its clade known to attack vertebrates. However, little is known about the molecular det...
متن کاملGenomic innovations linked to infection strategies across emerging pathogenic chytrid fungi
To understand the evolutionary pathways that lead to emerging infections of vertebrates, here we explore the genomic innovations that allow free-living chytrid fungi to adapt to and colonize amphibian hosts. Sequencing and comparing the genomes of two pathogenic species of Batrachochytrium to those of close saprophytic relatives reveals that pathogenicity is associated with remarkable expansion...
متن کاملChytrid Fungus in Europe
Eugene Athan,* Anthony M. Allworth,† Catherine Engler,‡ Ivan Bastian,§ and Allen C. Cheng*¶ *The Geelong Hospital, Geelong, Victoria, Australia; †Royal Brisbane Hospital, Brisbane, Queensland, Australia; ‡Queensland Health Pathology Services, Townsville, Queensland, Australia; §Institute of Medical and Veterinary Science, Adelaide, South Australia, Australia; and ¶Menzies School of Health Resea...
متن کاملChytrid fungi construct actin-rich pseudopods, implicating actin regulators WASP and SCAR in an ancient mode of cell motility
The manuscript titled “Chytrid fungi construct actin-rich pseudopods, implicating actin regulators WASP and SCAR in an ancient mode of cell motility” aims to investigate a specific mode of pseudopod-driven cell motility, coined α-motility, and to establish nucleation promoting factors WASP and SCAR/WAVE as its evolutionary signature. While SCAR’s role in pseudopod formation is firmly establishe...
متن کاملChytrid fungi construct actin-rich pseudopods, implicating actin regulators WASP and SCAR in an ancient mode of cell motility
Various cells scattered throughout the eukaryotic tree crawl across surfaces or through threedimensional environments. Evidence now indicates that cell crawling is not a single behavior, but rather a collection of processes, driven by different molecular mechanisms. Understanding these mechanisms and their evolutionary relationships first requires narrowly defining mechanical modes of locomotio...
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ژورنال
عنوان ژورنال: Current Biology
سال: 2020
ISSN: 0960-9822
DOI: 10.1016/j.cub.2020.02.076