Chronicle updates in cyclodextrin-based carriers for drug delivery
نویسندگان
چکیده
Abstract Background Cyclodextrins offer a range of biomedical applications in the pharmaceutical and biotechnology industries. (CDs) are oligosaccharides composed glucose as repeating units (6–9 given terms α, β, γ δ, respectively). Its inner core size varies with type CD, this variation finds its fitness small- to larger-sized organic drug molecules resolve delivery problems. Employment CDs was conceptualized since initial development (Year 1891). However, very first product market 1976. not only act carrier or self-assembly hydrogel hybrid gels for hydrophobic drugs but also reported modifier gelling temperature agarose make it suitable delivery. Main body This review represents trend research on reference Phase I (1975–1980) CD shows inclination towards β-CD inclusion complex wide drugs. Decade phase II (1981–1990) worked majorly other natural glimpse derivative system. Critical literature surveys from years 1991–2000 (phase III) provide visualization derivatives supported animal studies. IV (2001–2010) can be attributed golden period extreme exploitation many novel systems (aerosols, microemulsion, polymeric nanoparticles, osmotic pumps, sustain release), while most last decade were observed association nanoscale systems. Conclusions In view incessant utilization wider including carrier, gel, gel nano-composite properties, chronicle update knowledge database would inspire researchers multidisciplinary research. To sum up, almost every emerging system near future will earnest effort take advantage properties their better efficacy, stability, prevention toxicity patient acceptability.
منابع مشابه
Cyclodextrin-gantrez Nanoparticles as Bioadhesive Carriers for Oral Drug Delivery
Introduction Oral delivery is the most convenient and desired way for drug delivery. The major factor determinant for bioavailability of orally administered drug is the membrane permeability and drug solubility in the intestinal lumen. Many drugs show bioavailability problems due to their low water solubility, slow dissolution rate and instability in the gastrointestinal tract. One possibility ...
متن کاملCyclodextrin-based nanosponges as drug carriers
Cyclodextrin-based nanosponges, which are proposed as a new nanosized delivery system, are innovative cross-linked cyclodextrin polymers nanostructured within a three-dimensional network. This type of cyclodextrin polymer can form porous insoluble nanoparticles with a crystalline or amorphous structure and spherical shape or swelling properties. The polarity and dimension of the polymer mesh ca...
متن کاملCyclodextrin/poly(anhydride) nanoparticles as drug carriers for the oral delivery of atovaquone.
The aim was to study the ability of bioadhesive cyclodextrin-poly(anhydride) nanoparticles as carriers for the oral delivery of atovaquone (ATO). In order to increase the loading capacity of ATO by poly(anhydride) nanoparticles, the following oligosaccharides were assayed: 2-hydroxypropyl-β-cyclodextrin (HPCD), 2,6-di-O-methyl-β-cyclodextrin (DCMD), randomly methylated-β-cyclodextrin (RMCD) and...
متن کاملCyclodextrin In Drug Delivery: A Review
Cyclodextrins (CDs) are a family of cyclic oligosaccharides composed ofα-(1, 4) linked glucopyranose subunits. CDs have been found as potential candidates because of their ability to alter physical, chemical and biological properties of guest molecules through the formation of inclusion complexes. Pure cyclodextrins that were suitable for pharmaceutical applications did not come available until...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Bulletin of the National Research Centre
سال: 2022
ISSN: ['2522-8307', '1110-0591']
DOI: https://doi.org/10.1186/s42269-022-00904-y