Chronic wound

Approach to chronic wound infections.

Infection is the likeliest single cause of delayed healing in healing of chronic open wounds by secondary intention. If neglected it can progress from contamination to colonization and local infection through to systemic infection, sepsis and multiple organ dysfunction syndrome, and it can be life-threatening. Infection in chronic wounds is not as easy to define as in acute wounds, and is compl...

Small Intestinal Submucosa Wound Matrix for Chronic Wound Healing.

Chronic wounds represent a state where healing has stagnated. Venous, diabetic, and pressure ulcers are typically difficult to heal and are at high risk of becoming chronic. In an attempt to restart the healing of chronic wounds, many biologically important molecules, such as collagen, hyaluronic acid, and growth factors have been used to treat these wounds with varying degrees of success. Unti...

Persistence of the chronic wound – implicating biofilm

Chronic wounds by their very nature are recalcitrant and resistant to treatment. The pervading illness and pathology associated with the particular background disease, be it venous insufficiency, diabetes or the pathology underlying pressure ulcers have in the past been used as an explanation for non-healing and chronicity in these wounds. Thus managing poor perfusions, nutrition, sugar control...

Chronic wound pain and palliative cancer care.

Chronic Wound Colonization, Infection, and Biofilms

The term “chronic wound” is generally accepted, but yet no simple definition has been agreed upon. A mechanistic definition such as “those not following normal wound healing trajectory” have been proposed but the most common definition have been “ulcers (wounds) older than 3 months of age”. Indeed, some ulcers have been present for years. One to two percent of the population in the developed co...