Chronic tobacco smoking and gender as variables affecting amantadine disposition in healthy subjects.
نویسندگان
چکیده
منابع مشابه
Chronic tobacco smoking and gender as variables affecting amantadine disposition in healthy subjects.
Amantadine HCl (3 mg kg-1) was administered orally to 20 young healthy adults. Its apparent volume of distribution (V2/F) was higher in smokers than nonsmokers, 6.05 +/- 0.86 vs 4.87 +/- 0.85 l kg-1; (mean +/- s.d., 10/group, P < 0.011), and no gender-associated effect was observed. Renal clearance did not vary with time-interval, but urinary recovery at 48 h was higher in men than in women (60...
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ژورنال
عنوان ژورنال: British Journal of Clinical Pharmacology
سال: 1995
ISSN: 0306-5251
DOI: 10.1111/j.1365-2125.1995.tb04414.x