Chronic Recurrent Multifocal Osteomyelitis: A Comprehensive Literature Review
نویسندگان
چکیده
Chronic recurrent multifocal osteomyelitis (CRMO) is a non-infectious, inflammatory disorder of the bones. CRMO typically affects children, with predisposition to females. Bone-related pain often felt in metaphysis long bones, particularly lower extremities, but it can also target other sites at varied time intervals. Patients are likely complain tenderness and swelling that may cause considerable disability adversely impact quality life. There three main pathophysiological mechanisms have been hypothesized drive including imbalanced cytokine expression, increased inflammasome activation, enhanced osteoclast differentiation. Therapies based on targeting suppressing these key players patients. The first step management involves control. Non-steroidal anti-inflammatory drugs should provide initial relief, albeit temporarily. It imperative initiate immunosuppressive medication will help limit bone involvement thereby prevent development fractures or leg-length discrepancies, for example. purpose this literature review study pathophysiology carefully dissect agents previously employed This could allow purposeful formulation individualized care plans improving overall well-being authors included multitude PubMed-indexed articles published from 2000 onwards review.
منابع مشابه
Chronic Recurrent Multifocal Osteomyelitis in a 9-year-old Boy
Chronic recurrent multifocal osteomyelitis (CRMO) is a rare aseptic, auto-inflammatory bone disorder. CRMO presents with bone pain with or without fever. The diagnosis of CRMO is a diagnosis of exclusion and should be included in the differential diagnosis of chronic inflammatory bone lesions in children. Cultures of the bone are typically sterile, antibiotic therapy does not result in clinic...
متن کاملChronic recurrent multifocal osteomyelitis: 17 case reports and literature review
Results CRMO primarily affects girls with a mean age at onset of 8.5 years and a mean time to diagnosis of 8.5 months. Most patients were diagnosed in less than 1 month, but 2 cases presented a delay due to atypical presentation. At onset, 14 patients had inflammatory pain and 6 local swelling and fever. The lower limbs were predominantly affected, followed by the axial skeleton, the upper limb...
متن کاملChronic recurrent multifocal osteomyelitis.
Chronic recurrent multifocal osteomyelitis is an autoinflammatory disorder characterized by bone pain and fever, a course of exacerbations and remissions, and a frequent association with other inflammatory conditions. Because its etiology is largely unknown, the diagnosis is still based on clinical criteria; treatment is empiric and not always successful. The diagnosis is supported by the prese...
متن کاملChronic recurrent multifocal osteomyelitis; manifestation, imaging and diagnosis
Chronic recurrent multifocal osteomyelitis (CRMO) is an inflammatory bone disease usually affecting children. A 9-year old boy presented with recurrent lower extremities pain and discomfort lasting for two years. In every time, symptoms vanished after several weeks. The patient received antibiotics only in one period of bone pain. In other occasions the patient didn’t received any antibiotics. ...
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ژورنال
عنوان ژورنال: Cureus
سال: 2023
ISSN: ['2168-8184']
DOI: https://doi.org/10.7759/cureus.43118