Chronic phenacetin nephropathy.

Non-phenacetin analgesics and analgesic nephropathy

Background. A recent large-scale case-control study on analgesic nephropathy (SAN) [1] found no increased risk of end-stage renal disease (ESRD) in users of combined or single formulations of phenacetin-free analgesics. In a subgroup of 22 high users, however, a dose-dependent increased risk was found, which raised the question if these patients presented or not with analgesic nephropathy (AN)....

Analgesic nephropathy: removal of phenacetin from proprietary analgesics.

Since phenacetin was withdrawn from Askit Powders and Beecham's Powders in 1966 these preparations have declined in importance as a cause of analgesic nephropathy in Western Scotland. In most patients with analgesic nephropathy who persist in abuse of compound analgesics renal function continues to decline. The deterioration, however, is less rapid among those taking aspirin and caffeine mixtur...

Analgesic nephropathy. Clinical course after withdrawal of phenacetin.

Of 14 patients with analgesic nephropathy 11 were followed up for 9 to 88 (mean 36) months after withdrawal of analgesics containing phenacetin. Ten of these 11 are still alive and have improving, static, or very slowly declining renal function. Analgesic withdrawal is therefore worth achieving even in the presence of advanced renal failure. Careful prolonged follow-up is required to prevent or...

Phenacetin nephropathy in a patient with an ileostomy.

Phenacetin

Of many reports on the use of phenacetin, one by Dr. Freidrich Miiller?" Therapeutische Monatshefte," August 1888, is of unusual merit. He made numerous trials of the remedy in various diseases, and found that the temperature in adults was lowered by doses of seven to eleven grains, and seldom as much as fifteen grains was used. The fall in the temperature occurred within from one to four hours...