Chronic myelocytic and chronic lymphocytic leukemia
نویسندگان
چکیده
منابع مشابه
Chronic lymphocytic leukemia, biology, new diagnosis and treatment: review article
Chronic lymphocytic leukemia (CLL) is a malignancy of B CD5+cells and is the most common type of leukemia in adults. The disease is more common in men over 50 years in western countries. CLL is associated with defective apoptosis in B cells. CLL was traditionally regarded as a disease that occurs before naïve B cells meet the antigen in the lymph nodes. Laboratory diagnosis requires white blood...
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Introduction: CLL is one of the most common leukemias, which is categorized by the accumulation of mature CD5+ B-lymphocytes in the peripheral blood, bone marrow, and secondary lymphoid organs. In this study, the status of rs6449182 polymorphism of the CD38 gene and its association with clinical and laboratory parameters of CLL patients was evaluated. Methods: Genomic DNA extraction was perfor...
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Chronic myelocytic leukemia (CML)' is a clonal pluripotent stem cell disease, clinically divided into a chronic phase of a median duration of ^-4 yr, followed by an acute phase (blast crisis) lasting for few months (1) . Cytogenetic hallmark of most (95%) CML cases is the presence of the Philadelphia (Ph) chromosome, resulting from a reciprocal translocation between chromosomes 9 and 22 (2, 3) ...
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MicroRNAs are small, non-coding sequences that regulate gene expression by inducing degradation or translational inhibition of target mRNAs. These molecules control many intracellular physiological and pathological processes.Abnormal expression of these moleculs has been described in different cancers including hematopoietic cancers. According to the type of cancer and the stage, miRNA’s expres...
متن کاملA longitudinal comparison of antibodies to Epstein-Barr virus and clinical parameters in chronic lymphocytic leukemia and chronic myelocytic leukemia.
Elevated titers to the Epstein-Barr virus dividuals. No significant antibody changes have previously been reported in a numwere detected in the 20 CML patients ber of lymphoproliferative diseases, inor 23 of the 24 CLL patients who were cluding Burkitt’s lymphoma, infectious followed for a period of time up to 5 yr. mononucleosis, and Hodgkin’s disease. It appears that the elevated EBV titers T...
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ژورنال
عنوان ژورنال: Cancer
سال: 1972
ISSN: 0008-543X,1097-0142
DOI: 10.1002/1097-0142(197212)30:6<1583::aid-cncr2820300625>3.0.co;2-f