Chronic Meningococcal Septicaemia

Meningitis and meningococcal septicaemia.

Neisseria meningitidis accounted for over half the 2,360 notified cases of meningitis in England and Wales in 19971 and is the leading infectious cause of death in childhood2–4. There were twice as many notifications of meningococcal disease in 1997 as in 1994 and the mortality remained at around 10% (ca 240 deaths)1,2. This article focuses on the presentation and management of meningococcal di...

Heparin therapy in meningococcal septicaemia.

Hunter, J. (1973). Archives of Disease in Childhood, 48, 233. Heparin therapy in meningococcal septicaemia. Two cases of meningococcaemia with bad prognostic signs are presented. In one child a state of disseminated intravascular coagulation and defibrinogenation was established. Heparin therapy was used early and successfully in both cases, supporting the value of early anticoagulation in the ...

Fulminating meningococcal septicaemia presenting with subarachnoid haemorrhage.

Antoine, B., and Neveu, T. (1968). Journal of Laboratory and Clinical Medicine, 71, 101. Aoyagi, T., and Lowenstein, L. M. (1968). Journal of Laboratory and Clinical Medicine, 71, 686. Blanc, W. A., and Johnson, L. (1959). Journal of Neuropathology and Experimental Neurology, 18, 165. Carbone, J. V., and Grodsky, G. M. (1957). Proceedings of the Society for Experimental Biology and Medicine, 94...

Gamma-M deficiency predisposing to meningococcal septicaemia.

Pathophysiology and management of meningococcal septicaemia.

Whilst an infecting organism may produce toxins which injure tissues directly, this is often inadequate to explain the clinico-pathological sequelae in severe sepsis. Instead, the dominant role in pathogenesis may lie with components of the host immune response to infection. The highly conserved responses of the innate immune system comprise sequential activation and amplification of humoral an...