Chronic lymphocytic leukemia (CLL) treatment: So many choices, such great options
نویسندگان
چکیده
منابع مشابه
Chronic Lymphocytic Leukemia (CLL): Upfront Treatment Options in 2017
Submit Manuscript | http://medcraveonline.com Abbreviations: CLL: Chronic Lymphocytic Leukemia; FCR: Fludarabine, Cyclophosphamide and Rituximab; PI3K: Phosphatidylinositol 3-kinase; IWCLL: International Workshop on Chronic Lymphocytic Leukemia; CIRS: Cumulative Illness Rating Scale; CIT: chemoimmunotherapy; FISH: Fluorescence In Situ Hybridization; PFS: Progression Free Survival; EMA: European...
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CLL therapy has changed dramatically over the last few years. This development has been aided by progress in 2 areas: (1) a better understanding of CLL biology (and with it discovery and characterization of new prognostic markers); and (2) emergence of novel agents. The combined impact of advances in these areas is leading to new concepts and approaches in CLL therapy. Treatment of CLL has been...
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For the past ten years, there has been a dynamic development of new therapeutic compounds and prognostic parameters for chronic lymphocytic leukemia (CLL). Hematologists and oncologists are challenged to use these new possibilities for an optimized, risk- and fitness-adapted treatment strategy, with the goal of achieving long-term remissions and preserving a good quality of life. This review is...
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Chronic lymphocytic leukemia (CLL) affects the B-cells of the immune system and is, as the most common leukemia in adults, an important hematological differential diagnosis. It often hardly progresses for years and therefore a CLL does not always need immediate therapy. In the past years especially, a lot has happened with regard to diagnostic options and treatment, so that being informed about...
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Antigen stimulation of the leukemic clone is increasingly implicated in the pathogenesis of CLL. Chen and colleagues provide evidence that expression of ZAP-70 in CLL B cells renders IgM signaling more effective and thereby could contribute to the more rapidly progressive clinical course of ZAP-70-positive CLL.
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ژورنال
عنوان ژورنال: Cancer
سال: 2019
ISSN: 0008-543X,1097-0142
DOI: 10.1002/cncr.31931