Chronic Effects of Loxapine, Iloperidone, Paliperidone on Mice Isolated Vas Deferens Contractility
نویسندگان
چکیده
Objective: Erectile dysfunction is a usual side effect of antipsychotic medications; this causes patients to avoid using drugs. The aim study investigate the effects iloperidone, paliperidone and loxapine on serotonin (5-HT), noradrenaline (NA), adenosine triphosphate (ATP) potassium chloride (KCl)-induced contractions vas deferens in mice.Materials Methods: mice were randomly divided into experimental groups treated by ip injection drugs for 21 days. After treatment, investigated 5-HT, ATP, NA KCl-induced contractile responses epididymal prostatic portions strips. Results: 5-HT-induced significantly increased while ATP-induced decreased both obtained from loxapine-treated groups. However, these had no significant NA- deferens. Conclusion: These results showed that affected chronic treatments paliperidone, loxapine. In chronically with drugs, serotonergic purinergic receptors may contribute changes cause erectile dysfunction.
منابع مشابه
Cyclophosphamide Treatment Alters the Contractility of Isolated Rat Vas Deferens.
Influence of cyclophosphamide treatment (40. mg/kg, ip on alternate days for 5 times) was assessed on 1 m mol BaCl2-induced in vitro rhythmic contractions in isolated rat vas deferens. The mean frequency (contractions per min) and amplitude (g tension) of rhythmic contractions were significantly decreased in the tissues isolated from cyclophosphamide-treated rats as compared to the control tiss...
متن کاملPT648. The effects of chronic treatment with haloperidol, clozapine and aripiprazole on mice isolated vas deferens
s | 37 2. Hahn, A., G.S. Kranz, R. Sladky, U. Kaufmann, S. Ganger, et al., Long-term testosterone administration affects language areas of the human brain. Hum Brain Mapp, 2016(accepted). 3. Rametti, G., B. Carrillo, E. Gomez-Gil, C. Junque, L. ZubiaurreElorza, et al., Effects of androgenization on the white matter microstructure of female-to-male transsexuals. A diffusion tensor imaging stud...
متن کاملA comparative study on the effects of new opioid compounds and morphine on the contractility of guinea pig ileum and mouse vas deferens
Considering the clinical significance of opioids, especially their application for the treatment of severe painful conditions including cancer pain and the requirement for the synthesis of more specific drugs with lower side effects, this study was conducted to perform a preliminary investigation on six newly developed opioid drugs. Our aim was to introduce drugs that act selectively on the opi...
متن کاملEffects of methamphetamine on the twitch response in the rat isolated vas deferens.
The effect of methamphetamine, an indirectly acting sympathomimetic amine, on presynaptic adrenergic regulation in isolated rat vas deferens was studied by comparing it with those of tyramine, cocaine and clonidine. These drugs markedly attenuated the twitch response to electrical field stimulation in a concentration-dependent manner. The relative order of potency for the drugs was: clonidine (...
متن کاملEffects of long-term treatment with fluoxetine and venlafaxine on rat isolated vas deferens.
Antidepressant therapy is considered as one of the factors leading to male infertility. In this study, the effects of long-term treatment with fluoxetine or venlafaxine were investigated on electrical field stimulation (EFS, 1-64 Hz), noradrenaline (10(-8) to 10(-4) M), serotonin (10(-8) to 10(-4) M), adenosine 5'-triphosphate [ATP (10(-8) to 10(-4) M)] and 80 mM KCl-induced contractile respons...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Online türk sa?l?k bilimleri dergisi
سال: 2022
ISSN: ['2459-1467']
DOI: https://doi.org/10.26453/otjhs.987184