Chronic Effects of Atypic Antipsychotics on Mice Isolated Vas Deferens Contractility: An In vitro Study

Aims: Antipsychotic drugs are known to be commonly associated with sexual dysfunction. The aim of this study investigate the effects sertindole, asenapine and ziprasidone on serotonin (5-HT), noradrenaline (NA), adenosine triphosphate (ATP) potassium chloride (KCl)-induced contractions isolated vas deferens in mice.
 Study design: All were administered intraperitoneally (i.p.) a volume 0.1 ml per 10 g body weight Place Duration Study: Department Pharmacology, Kocaeli University, Animal Research Center, between May 2018 August 2019.
 Methodology: mice randomly divided into groups (n=7) as follows: saline; sertindole 1.3 mg/kg; 2.5 0.05 0.075 1 2 mg/kg once daily for 21 days. Mice receiving only vehicle (0.9% saline, i.p.) served control group. After days treatment, investigated 5-HT, NA, ATP KCl-induced deferens.
 Results: results showed that serotonin-induced affected by chronic treatments ziprasidone, however these had no significant effect ATP, Conclusion: Serotonergic receptors may contribute changes treatment ziprasidone. Thus, our explain one causes dysfunction