Chronic Cyclical Granulopenia

Granulopenia and Sulfa Drugs

Cannabinoid hyperemesis: cyclical hyperemesis in association with chronic cannabis abuse.

BACKGROUND AND AIMS To explore the association between chronic cannabis abuse and a cyclical vomiting illness that presented in a series of cases in South Australia. METHODS Nineteen patients were identified with chronic cannabis abuse and a cyclical vomiting illness. For legal and ethical reasons, all patients were counselled to cease all cannabis abuse. Follow up was provided with serial ur...

Cyclical granulopoiesis in chronic granulocytic leukemia: a simulation study.

There exists ample evidence that granulopoiesis is an actively controlled process. The observation of cyclical granulopoiesis in chronic granulocytic leukemia (CGL) suggests that control is deranged rather than abolished in this disorder. Analysis of the kinetics of granulopoiesis in CGL may provide some insight into the nature of the derangement. To facilitate analysis, a mathematical model of...

Cyclical caspofungin for chronic pulmonary aspergillosis in sarcoidosis.

In sarcoidosis, chronic pulmonary aspergillosis (CPA) may be associated with significant morbidity, and treatment failure rates are often high, even with newer triazole antifungal agents. We report a treatment regimen of cyclical caspofungin infusions in 10 patients with sarcoidosis and worsening CPA despite oral triazoles.

Experimental Granulopenia, Due to Bacterial Toxins Elaborated in Vivo

Pyogenic organisms, under conditions simulating a focal infection, are capable of producing in rabbits a granulopenia which may allow generalized infection and death. It is suggested that agranulocytosis in man is due to the action of leucocidin, rather than to a specific microorganism.