Chronic Clomipramine Treatment Reverses Core Symptom of Depression in Subordinate Tree Shrews
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منابع مشابه
Chronic Clomipramine Treatment Reverses Core Symptom of Depression in Subordinate Tree Shrews
Chronic stress is the major cause of clinical depression. The behavioral signs of depression, including anhedonia, learning and memory deficits, and sleep disruption, result from the damaging effects of stress hormones on specific neural pathways. The Chinese tree shrew (Tupaia belangeri chinensis) is an aggressive non-human primate with a hierarchical social structure that has become a well-es...
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We have shown previously that repeated laboratory restraint stress or daily corticosterone administration affects the structure of CA3 hippocampal neurons in rats. In the present study, we investigated the effect of repeated daily psychosocial stress on the structure of hippocampal CA3 pyramidal neurons in male tree shrews (Tupaia belangeri). Male tree shrews develop social hierarchies in which...
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Depression is a common neuropsychiatric disorder, marked by depressed mood for at least two weeks. The World Health Organization predicts that depression will be the number one leading cause of disease and injury burden by 2030. Clinical treatment faces at least three serious obstacles. First, the disease mechanism is not fully understood and thus there are no effective ways to predict and prev...
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To improve our knowledge of the causal mechanisms of stress-related disorders such as depression, we need animal models that mirror the situation in patients. One promising model is the chronic psychosocial stress paradigm in male tree shrews, which is based on the territorial behaviour of these animals that can be used to establish naturally occurring challenging situations under experimental ...
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Animals exposed to stress are considered to be models for depression. In humans, stress is thought to initiate or exacerbate a number of psychiatric disorders such as post-traumatic stress syndrome or major depression. To improve our knowledge of the causal mechanisms of stress-related disorders, and to bridge the gap between experimental models and the situation in humans, we need naturalistic...
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ژورنال
عنوان ژورنال: PLoS ONE
سال: 2013
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0080980