Chronic beryllium disease: diagnosis and management.

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Chronic beryllium disease: diagnosis and management.

Chronic beryllium disease is predominantly a pulmonary granulomatosis that was originally described in 1946. Symptoms usually include dyspnea and cough. Fever, anorexia, and weight loss are common. Skin lesions are the most common extrathoracic manifestation. Granulomatous hepatitis, hypercalcemia, and kidney stones can also occur. Radiographic and physiologic abnormalities are similar to those...

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An official American Thoracic Society statement: diagnosis and management of beryllium sensitivity and chronic beryllium disease.

RATIONALE Beryllium continues to have a wide range of industrial applications. Exposure to beryllium can lead to sensitization (BeS) and chronic beryllium disease (CBD). OBJECTIVES The purpose of this statement is to increase awareness and knowledge about beryllium exposure, BeS, and CBD. METHODS Evidence was identified by a search of MEDLINE. The committee then summarized the evidence, dre...

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Chronic beryllium disease: uncommon disease, less common diagnosis.

Chronic beryllium disease (CBD) is typically considered only when occupational exposure to beryllium is a certainty; however, CBD has also occurred in occupational and environmental settings where exposure was unexpected. When the etiology of a case of granulomatous pulmonary disease is not determined, sarcoidosis is the "diagnosis of exclusion." This diagnosis does not communicate much informa...

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Beryllium Sensitization Progresses to Chronic Beryllium Disease

The blood beryllium lymphocyte proliferation test is used in medical surveillance to identify both beryllium sensitization and chronic beryllium disease. Approximately 50% of individuals with beryllium sensitization have chronic beryllium disease at the time of their initial clinical evaluation; however, the rate of progression from beryllium sensitization to chronic beryllium disease is unknow...

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Clinical Guideline for the Diagnosis of Beryllium Sensitization and Chronic Beryllium Disease

This Guideline provides the clinical diagnostic criteria for beryllium sensitization and chronic beryllium disease (CBD; old term = berylliosis), based on the latest available medical literature and consultation with leading experts in the field. This Guideline does not address exposure prevention, workplace safety, or treatment. In addition, this Guideline is not intended to supplant all adjud...

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ژورنال

عنوان ژورنال: Environmental Health Perspectives

سال: 1996

ISSN: 0091-6765,1552-9924

DOI: 10.1289/ehp.96104s5945