Chronic antibody rejection in renal allograft: An underestimated cause of renal allograft dysfunction
نویسندگان
چکیده
منابع مشابه
Chronic renal allograft dysfunction.
The major causes of renal transplant loss are death from vascular, malignant or infectious disease, and loss of the allograft from chronic renal dysfunction associated with the development of graft fibrosis and glomerulosclerosis. Chronic allograft nephropathy (CAN) is the histologic description of the fibrosis, vascular and glomerular damage occurring in renal allografts. Clinical programs rel...
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tient’s baseline anticoagulant therapy contributed to the unusually slow progression of vision loss. A few reports propose beneficial effects of anticoagulation and antiplatelet therapy in GCA-related vision loss. Buono et al reported improvement in acuity and posterior ciliary artery blood flow with the addition of heparin sodium therapy in a patient with progressive visual loss despite cortic...
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Rejection is the major cause of graft failure, and if the injury to the tubules and glomeruli is severe, the kidney may not recover. It is therefore important to diagnose acute rejection as soon as possible to institute prompt antirejection therapy. Generally, the success with which rejection can be reversed by immunosuppressive agents determines the chance of long-term success of the transplan...
متن کاملTreatment of acute renal allograft rejection with OKT3 monoclonal antibody.
Eight cadaver donor renal allograft recipients, who had received azathioprine and prednisone from the day of transplantation, were treated with OKT3 monoclonal antibody (reactive with all mature peripheral blood T cells) at the time of diagnosis of acute rejection. In all cases, loss of essentially all detectable peripheral blood OKT3-reactive cells was noted within minutes after the initial 1-...
متن کاملTHE ROLE OF T-L YMPHOCYTE SUBPOPULATION IN RENAL ALLOGRAFT REJECTION
Twenty-two recipients of HLA-nonidentical living related and nonrelated renal allografts were studied for alterations in the relative percentage of OKT4-positive peripheral blood T-cells after transplantation. Characteristic shifts in the ratio of T-helper to T -suppressor/cytotoxic cells (TH/TS-C), but not absolute cell numbers, were demonstrated to correspond with the status of the allog...
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ژورنال
عنوان ژورنال: Indian Journal of Transplantation
سال: 2019
ISSN: 2212-0017
DOI: 10.4103/ijot.ijot_66_18