Chromothripsis in Treatment Resistance in Multiple Myeloma
نویسندگان
چکیده
منابع مشابه
Chromothripsis in Treatment Resistance in Multiple Myeloma
Multiple myeloma (MM) is a malignant disease caused by an abnormal proliferation of plasma cells, of which the prognostic factors include chromosomal abnormality, β-2 microglobulin, and albumin. Recently, the term chromothripsis has emerged, which is the massive but highly localized chromosomal rearrangement in response to a one-step catastrophic event. Many studies have shown an association of...
متن کاملTreatment of Multiple Myeloma
Les traitements classiques de myelome multiple et les schemas differents proposes ont ete mis en revue. La poly chimiotherapie de la maladie avec une com-binaison de cyclophosphamide, B.C.N.U. Alkeran, Perdnisone et Vincristine a donnee une meilleur Resultat ceci surtout dans les formes graves et rapidement progressive de la maladie. D'autres sehemas therapeutiques sont en cours.
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Maintenance chemotherapy has failed to demonstrate any benefit [1, 2]. Corticosteroid maintenance was found to prolong the duration of response; however, the effect on survival was controversial [3, 4]. Interferon-a represented a great hope in the 1980s but metaanalysis of randomized trials showed a modest increase in progression-free survival (PFS) and a minimal benefit in overall survival (OS...
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This literature review presents the most recent developments in the management of multiple myeloma, which is characterized by the presence of abnormal plasma cells (myeloma cells) that accumulate into the bone marrow. Aspects related to pathophysiology, clinical manifestations, laboratory, study and treatment are described. These pieces of information are necessary to accomplish a better ...
متن کاملMolecular mechanisms in multiple myeloma drug resistance.
Multiple myeloma (MM) is predominantly an incurable malignancy despite high-dose chemotherapy, autologous stem cell transplant and novel agents. MM is a genetically heterogeneous disease and the complexity increases as the disease progresses to a more aggressive stage. MM arises from a plasma cell, which produces and secretes non-functioning immunoglobulins. Most MM cells are sensitive to prote...
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ژورنال
عنوان ژورنال: Genomics & Informatics
سال: 2017
ISSN: 2234-0742
DOI: 10.5808/gi.2017.15.3.87